Challenges of neuropathic pain
| Jazyk: | angličtina |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Spinal sensitization
Personalized pain management PERIPHERAL-NERVE INJURY Quantitative sensory testing RANDOMIZED CONTROLLED-TRIAL ALPHA-LIPOIC ACID DIAGNOSE DISTAL POLYNEUROPATHY DOUBLE-BLIND Neuroinflammation Painful diabetic neuropathy GATED SODIUM-CHANNELS CONTROLLED-RELEASE OXYCODONE GERMAN RESEARCH NETWORK PROTEIN-KINASE-C Stratification in clinical trials HUMAN SURROGATE MODELS |
| Zdroj: | Journal of Neural Transmission. 127(4):589-624 |
| ISSN: | 1435-1463 0300-9564 |
| Popis: | Neuropathic pain is a frequent condition caused by a lesion or disease of the central or peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain is diabetic neuropathy. Its complex pathophysiology is not yet fully elucidated, which contributes to underassessment and undertreatment. A mechanism-based treatment of painful diabetic neuropathy is challenging but phenotype-based stratification might be a way to develop individualized therapeutic concepts. Our goal is to review current knowledge of the pathophysiology of peripheral neuropathic pain, particularly painful diabetic neuropathy. We discuss state-of-the-art clinical assessment, validity of diagnostic and screening tools, and recommendations for the management of diabetic neuropathic pain including approaches towards personalized pain management. We also propose a research agenda for translational research including patient stratification for clinical trials and improved preclinical models in relation to current knowledge of underlying mechanisms. |
| Databáze: | OpenAIRE |
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