Genetic Modification Approaches for Parasporins Bacillus thuringiensis Proteins with Anticancer Activity

Jazyk:	angličtina
Rok vydání:	2021
Předmět:	MODIFIED BT TOXINS genetic improvement PURIFICATION DELTA-ENDOTOXIN IDENTIFICATION CRYSTAL PROTEIN parasporins CANCER INCLUSIONS DOMAIN-III cancer cells CYTOTOXIC PROTEIN Cry toxins SPECIFICITY
Zdroj:	Molecules. 26(24)
ISSN:	1420-3049 1431-5157
Popis:	Bacillus thuringiensis (Bt) is a bacterium capable of producing Cry toxins, which are recognized for their bio-controlling actions against insects. However, a few Bt strains encode proteins lacking insecticidal activity but showing cytotoxic activity against different cancer cell lines and low or no cytotoxicity toward normal human cells. A subset of Cry anticancer proteins, termed parasporins (PSs), has recently arisen as a potential alternative for cancer treatment. However, the molecular receptors that allow the binding of PSs to cells and their cytotoxic mechanisms of action have not been well established. Nonetheless, their selective cytotoxic activity against different types of cancer cell lines places PSs as a promising alternative treatment modality. In this review, we provide an overview of the classification, structures, mechanisms of action, and insights obtained from genetic modification approaches for PS proteins.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dris___01423::6d852c517061de0333ca7180cb057883 https://research.rug.nl/en/publications/34160807-d3e4-4aaf-a34e-160432c0ec39 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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