Working memory network alterations in high-functioning adolescents with an autism spectrum disorder

Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Male Adolescent Autism Spectrum Disorder/diagnostic imaging Cerebral Cortex/diagnostic imaging higher functioning Functional Neuroimaging/methods autism spectrum disorder Nerve Net/diagnostic imaging SDG 3 – Goede gezondheid en welzijn functional magnetic resonance imaging Magnetic Resonance Imaging working memory SDG 3 - Good Health and Well-being Memory Humans Female Asperger Syndrome/diagnostic imaging Short-Term/physiology Child network analysis
Zdroj:	Psychiatry and Clinical Neurosciences. 72(2):73-83
ISSN:	1440-1819 1323-1316
Popis:	Aim: People with autism spectrum disorder (ASD) typically have deficits in the working memory (WM) system. WM is found to be an essential chain in successfully navigating in the social world. We hypothesize that brain networks for WM have an altered network integrity in ASD compared to controls. Methods: Thirteen adolescents (one female) with autistic disorder (n = 1), Asperger's disorder (n = 7), or pervasive developmental disorder not otherwise specified (n = 5), and 13 typically developing healthy control adolescents (one female) participated in this study. Functional magnetic resonance imaging (MRI) was performed using an n-back task and in resting state. Results: The analysis of the behavioral data revealed deficits in WM performance in ASD, but only when tested to the limit. Adolescents with ASD showed lower binary global efficiency in the WM network than the healthy control group with n-back and resting-state data. This correlated with diagnostic scores for total problems, reciprocity, and language. Conclusion: Adolescents with higher-functioning autism have difficulty with the WM system, which is typically compensated. Functional MRI markers of brain network organization in ASD are related to characteristics of autism as represented in diagnostic scores. Therefore, functional MRI provides neuronal correlates for memory difficulties in adolescents with ASD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dris___01180::cf87dc74aeb5741a078c84ec1025ecd9 https://research.tue.nl/en/publications/b830917b-6d88-48e1-962c-22be1273214a Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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