Unconventional endocytic mechanisms
| Jazyk: | angličtina |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Macropinocytosis
Ultrafast endocytosis Glycolipid-Lectin hypothesis Glycosylphosphatidylinositol-anchored proteins Activity-dependent bulk endocytosis Clathrin-independent carriers/GPI-AP-enriched early endosomal compartments (CLIC/GEEC) Lipids Clathrin Clathrin-mediated endocytosis Endocytosis Cargoes Clathrin-independent endocytosis EGFR Non-Clathrin endocytosis Interleukin-2 receptor endocytosis Massive Endocytosis Receptors Endophilin-A3/Galectin-8-mediated endocytosis Fast endophilin-mediated endocytosis (FEME) |
| Zdroj: | Current Opinion in Cell Biology. 71:120-129 |
| ISSN: | 1879-0410 0955-0674 |
| Popis: | Endocytosis mediates the uptake of extracellular proteins, micronutrients and transmembrane cell surface proteins. Importantly, many viruses, toxins and bacteria hijack endocytosis to infect cells. The canonical pathway is clathrin-mediated endocytosis (CME) and is active in all eukaryotic cells to support critical house-keeping functions. Unconventional mechanisms of endocytosis exit in parallel of CME, to internalize specific cargoes and support various cellular functions. These clathrin-independent endocytic (CIE) routes use three distinct mechanisms: acute signaling-induced membrane remodeling drives macropinocytosis, activity-dependent bulk endocytosis (ADBE), massive endocytosis (MEND) and EGFR non-clathrin endocytosis (EGFR-NCE). Cargo capture and local membrane deformation by cytosolic proteins is used by fast endophilin-mediated endocytosis (FEME), IL-2Rβ endocytosis and ultrafast endocytosis at synapses. Finally, the formation of endocytic pits by clustering of extracellular lipids or cargoes according to the Glycolipid-Lectin (GL-Lect) hypothesis mediates the uptake of SV40 virus, Shiga and cholera toxins, and galectin-clustered receptors by the CLIC/GEEC and the endophilin-A3-mediated CIE. |
| Databáze: | OpenAIRE |
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