Lack of effect of doxycycline on disease activity and joint damage in patients with rheumatoid arthritis. A double blind, placebo controlled trial
| Jazyk: | angličtina |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
musculoskeletal diseases
Pyridinolines Adult Male Biomedical Research crossover procedure double blind procedure Adolescent hand radiography Severity of Illness Index Drug Administration Schedule Dose-Response Relationship pyridinoline clinical examination Double-Blind Method Reference Values Rheumatoid 80 and over Humans controlled study Treatment Failure Rheumatoid arthritis foot radiography Aged Pain Measurement Analysis of Variance Chi-Square Distribution Cross-Over Studies doxycycline controlled clinical trial Arthritis scoring system clinical trial joint stiffness Middle Aged major clinical study Treatment Outcome Health laboratory test randomized controlled trial placebo Female erythrocyte sedimentation rate Drug deoxypyridinoline joint destruction disease activity Follow-Up Studies |
| Popis: | Objective. To investigate the effects of doxycycline on disease activity and joint destruction in patients with rheumatoid arthritis (RA). Methods. A 36 week double blind, placebo controlled crossover trial was conducted. Patients (n = 66) received 50 mg doxycycline or placebo twice a day during 12, 24, or 36 weeks. Patient assessments were performed before the treatment was administered, at 6, 12, 24 and 36 weeks of treatment, and finally at 4 weeks after cessation of treatment. Patient assessments, swollen and tender joint counts, duration of morning stiffness, erythrocyte sedimentation rate, and Modified Disease Activity Score were used as measures of disease activity. Effects on joint destruction were assessed by urinary excretion of the pyridinolines hydroxylysylpyridinoline and lysylpyridinoline and by scoring radiographic damage of hands and feet before and after treatment. Results. The changes of clinical or laboratory disease activity measures, pyridinoline excretion, or progression of radiographic joint damage during doxycycline or placebo treatment did not differ significantly. Conclusion. The results indicate that 50 mg doxycycline twice a day provided no therapeutic benefit for patients with RA. |
| Databáze: | OpenAIRE |
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