Effects of halopemide, a new psychotropic agent, on the uptake of serotonin by blood platelets
| Jazyk: | angličtina |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
1 [1 (2 aminoethyl) 4 piperidyl] 5 chloro 1
3 dihydro 1 (4 piperidinyl)benzimidazol 2(2h) one 5 chloro 1 (4 piperidyl) 1 in vitro study sulpiride animal experiment drug response thrombocyte serotonin serotonin creatinine sulfate c 14 4 fluorohippuric acid 3 dihydro 2h benzimidazol 2 one rat human radioisotope clozapine halopemide human cell drug comparison article r38570 serotonin unclassified drug imipramine thrombocyte serotonin c 14 n dimethylformamide drug metabolite 5 chloro 1 |
| Zdroj: | Archives internationales de pharmacodynamie et de therapie. 237(2):267-274 |
| ISSN: | 0003-9780 |
| Popis: | The influence of halopemide, a new psychotropic agent, and some putative metabolites on the uptake of14C-5-HT into blood platelets of rat and man were studied and compared to the effects of imipramine, sulpiride and clozapine. Halopemide, its putative metabolites R 38570 and R 29676 and sulpiride inhibited the uptake in a dose-dependent manner, but the compounds were less active than imipramine. Clozapine and p-fluorohippuric acid, another putative metabolite of halopemide, were totally devoid of activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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