Prostate cancer susceptibility genes on 8P21-23 in a Dutch population
| Jazyk: | angličtina |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Genotype Epidemiology Tumor gene Prostatic neoplasm/genetics Major clinical study Cancer staging LS - Life Style Animal tissue Cancer risk Advanced cancer LPL gene MTSG1 gene Aged Allele Msr1 gene Prostate cancer Microsatellite repeats/genetics Microsatellite marker disease association NKX3.1 gene Lipoprotein lipase Nonhuman BSS - Behavioural and Societal Sciences Polymerase chain reaction Health Chromosome 8p23 Genetic association Chromosome 8p22 Chromosome 8p21 Healthy for Life Controlled study Healthy Living Human |
| Popis: | Background:Prostate cancer is the most commonly diagnosed cancer in men in Europe and the United States. Numerous studies have indicated genetics to have a major role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have detected an association between prostate cancer and chromosome 8p21-23. In this study, we analysed eight microsatellite (MS) markers in that region in order to confirm previous results and narrow down the location of candidate prostate cancer genes.Methods:292 cases and 278 controls were selected from the Netherlands Cohort Study (NLCS). The following MSs were used in the analyses: D8S136, D8S1734, D8S1742, D8S261, D8S262, D8S351, D8S511 and D8S520. Associations were evaluated using a χ 2 test and logistic regression. We checked for any effects on the association by tumour stage.Results:Associations that were found confirmed previous research that pointed to the 8p21-23 region. Two MSs: D8S136 (odds ratio (OR), 0.69; P=4.00 × 10 -28), and D8S520 (OR, 0.80; P=3.37 × 10 -11), were consistently and strongly related with prostate cancer. Genotype analysis showed an additive effect for D8S136 (P-trend=6.22 × 10 -03) and D8S520 (P-trend=2.62 × 10 -22), suggesting an increased risk for people with a short number of repeats on both alleles at those markers.Conclusions:This study provides strong evidence that the 8p21-23 region is likely to harbour prostate cancer genes.© 2013 Macmillan Publishers Limited All rights reserved. Chemicals/CAS: lipoprotein lipase, 83137-80-8, 9004-02-8 |
| Databáze: | OpenAIRE |
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