Dietary supplement use and colorectal cancer risk: A systematic review and meta-analyses of prospective cohort studies
Jazyk: | angličtina |
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Rok vydání: | 2015 |
Předmět: |
Global Nutrition
Ecucation Support Wereldvoeding life-style Nutrition and Disease Library Research and Education Support vitamin-d combined folic-acid united-states Humane Voeding & Gezondheid base-line characteristics beta-carotene supplementation randomized-trial Voeding en Ziekte iowa womens health colon-cancer VLAG Human Nutrition & Health multivitamin use |
Zdroj: | International Journal of Cancer. 136(10):2388-2401 |
ISSN: | 0020-7136 |
DOI: | 10.1002/ijc.29277 |
Popis: | Use of dietary supplements is rising in countries where colorectal cancer is prevalent. We conducted a systematic literature review and meta-analyses of prospective cohort studies on dietary supplement use and colorectal cancer risk. We identified relevant studies in Medline, Embase and Cochrane up to January 2013. Original and peer-reviewed papers on dietary supplement use and colorectal cancer, colon cancer, or rectal cancer incidence were included. “Use-no use”(U-NU), “highest-lowest”(H-L) and “dose-response”(DR) meta-analyses were performed. Random-effects models were used to estimate summary estimates. In total, 24 papers were included in the meta-analyses. We observed inverse associations for colorectal cancer risk and multivitamin (U-NU: RR¿=¿0.92; 95% CI: 0.87,0.97) and calcium supplements (U-NU: RR¿=¿0.86; 95% CI: 0.79,0.95; H-L: RR¿=¿0.80; 95% CI: 0.70,0.92; DR: for an increase of 100 mg/day, RR¿=¿0.96; 95% CI: 0.94,0.99). Inconsistent associations were found for colon cancer risk and supplemental vitamin A and vitamin C, and for colorectal cancer risk and supplemental vitamin D, vitamin E, garlic and folic acid. Meta-analyses of observational studies suggest a beneficial role for multivitamins and calcium supplements on colorectal cancer risk, while the association with other supplements and colorectal cancer risk is inconsistent. Residual confounding of lifestyle factors might be present. Before recommendations can be made, an extensive assessment of dietary supplement use and a better understanding of underlying mechanisms is needed. |
Databáze: | OpenAIRE |
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