Selective oxyfunctionalisation reactions catalysed by P450 monooxygenases and peroxygenases – A bright future for sustainable chemical synthesis

Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Oxyfunctionalisation reactions Biocatalysis P450 monooxygenases Peroxygenases
Zdroj:	Current Opinion in Green and Sustainable Chemistry. 39
ISSN:	2452-2236
Popis:	Heme-dependent oxygenases (i.e. P450 monooxygenases and peroxygenases) are highly selective catalysts for the selective oxyfunctionalisation or organic compounds. Both enzyme classes exhibit mechanistic similarities (i.e. using so-called compound I (CpdI) as active oxidation species) and differences in how CpdI is formed. From the differences also practical differences arise which may influence the scalability, economic attractiveness and environmental impact of P450 monooxygenase- or peroxygenase-catalysed reactions. In this contribution we propose a range of performance indicators to compare the potential of both enzyme classes.
Databáze:	OpenAIRE
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