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Michal Hrdlicka,1 Jan Sanda,2 Tomas Urbanek,3 Martin Kudr,4 Iva Dudova,1 Stepanka Kickova,1 Lenka Pospisilova,1,5 Marketa Mohaplova,1 Alice Maulisova,4 Pavel Krsek,4 Martin Kyncl,2 Marek Blatny,1,6 Vladimir Komarek4 1Department of Child Psychiatry, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic; 2Department of Radiology, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic; 3Institute of Psychology, Academy of Sciences, Brno, Czech Republic; 4Department of Pediatric Neurology, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic; 5Charles University First Faculty of Medicine, Prague, Czech Republic; 6Department of Psychology, Faculty of Arts, Masaryk University, Brno, Czech RepublicCorrespondence: Michal HrdlickaDepartment of Child Psychiatry, Charles University Second Faculty of Medicine, University Hospital Motol, V Uvalu 84, Prague 15006, Czech RepublicTel +420 224 433 400Fax +420 224 433 420Email michal.hrdlicka@lfmotol.cuni.czBackground: Diffusion tensor imaging (DTI) is a powerful tool for investigating brain anatomical connectivity. The aim of our study was to compare brain connectivity among children with autism spectrum disorders (ASD), developmental dysphasia (DD), and healthy controls (HC) in the following tracts: the arcuate fasciculus (AF), inferior frontal occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), and uncinate fasciculus (UF).Methods: Our sample consisted of 113 children with a mean age 8.7±2.2 years (77 boys, 36 girls), divided into three subgroups: ASD (n=39), DD (n=36), and HC (n=38). The International Classification of Diseases, 10th ed. was used to make clinical diagnoses. DTI images were collected using a 1.5 T Phillips Achieva MR imaging system.Results: Detailed analyses of fractional anisotropy (FA) revealed significant differences among the ASD, DD, and HC groups in the left AF (p=0.014) and right AF (p=0.001), the left IFOF (p |
