| Popis: |
Oladapo A Adewuya,1 Rasaaq A Adebayo,1 Adeola I Ajibade,2 Gbenga J Odunlami,2 Anthony O Akintomide,1 Suraj A Ogunyemi,1 Olufemi E Ajayi,1 Adebola O Adetiloye,3 Adeleye D Omisore,4 Oladipo A Olanipekun,1 Adeyinka O Owolabi,1 Ifeoluwa Amjo,1 Olumide A Akinyele,1 Abayomi O Bamgboje,1 Michael O Balogun1 1Department of Cardiology, 2Department of Rheumatology, 3Department of Pulmonology, 4Department of Radiology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun, Nigeria Background: Mixed connective tissue disease (MCTD; also known as Sharp’s syndrome) is a rare autoimmune inflammatory disorder characterized by high titer of U1 ribonucleoprotein (U1RNP) antibody and clinical and serological overlap of systemic lupus erythematosus, systemic sclerosis, and polymyositis. The diagnosis is based on clinical and serological factors in criteria such as Alarcon-Segovia, Khan, Kusakawa, and Sharps. Cardiac disease can be a complication of connective tissue disease (CTD). There are few reports in Africa. Aims: To present MCTD as underlying cause of heart failure with reduced ejection fraction and highlight challenges of investigations and treatment. Objectives: To highlight the first case in our center and discuss the cardiac, respiratory, and rheumatologic management. Patient and methods: We present a 52-year-old woman with 3 weeks history of productive cough with whitish sputum, severe dyspnea, orthopnea, paroxysmal nocturnal dyspnea, right sided abdominal pain, leg swellings, a one year history of recurrent fever, Raynaud’s phenomenon, small joint swellings and deformities with pain in both hands. Results: On examination there was microstomia, tethered forehead and lower eyelid skin, tender swelling of the interphalangeal joints and arthritis mutilans. Laboratory findings showed estimated glomerular filtration rate |
