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Rohitha Moudgal,1 Andrew W Schultz,1 Eric D Shah2 1Department of Internal Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA; 2Section of Gastroenterology and Hepatology, Dartmouth-HitchcockHealth,One Medical Center Drive, Lebanon, NH, USACorrespondence: Eric D ShahCenter for Gastrointestinal Motility, Esophageal, and Swallowing Disorders, Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Health, One Medical Center Drive, Lebanon, NH, 03756, USATel +1 603 650-5261Fax +1 603 727-7925Email eric.d.shah@hitchcock.orgAbstract: Functional gastrointestinal disorders (FGID) are now classified within the Rome IV framework as disorders of gut–brain interaction (DGBI). Disorders of gastrointestinal transit (as defined by abnormalities on contemporary gastrointestinal motility testing) frequently are associated with symptoms that are also characteristic of DGBIs. In this narrative review, we outline a non-inclusive set of systemic diseases or risk factors that have been classically associated with DGBIs and disorders of gastrointestinal transit; these include diabetes mellitus, paraneoplastic syndromes, surgery, Parkinson’s disease, systemic sclerosis, endocrinopathies, polypharmacy, and post-infectious syndromes.Keywords: motility, neurogastroenterology, gastroenterology, mechanism |
