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Praveen J Patel,1 Focke Ziemssen,2 Eugene Ng,3 Anushini Muthutantri,4 David Silverman,5 Elizabeth A Tschosik,6 Ronald A Cantrell6 1NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, and University College London Institute of Ophthalmology, London, UK; 2University of Tuebingen, Tuebingen, Germany; 3Institute of Eye Surgery, UPMC Whitfield and Waterford Institute of Technology, Waterford, Ireland; 4IQVIA, London, UK; 5Roche Products Limited, Welwyn Garden City, Hertfordshire, UK; 6Genentech, Inc., A Member of the Roche Group, South San Francisco, CA, USACorrespondence: David SilvermanOphthalmology, Roche Products Limited, 6 Falcon Way, Shire Park, Welwyn Garden City AL7 1TW, UKTel +44 1707 36 6394Email david.silverman@roche.comPurpose: To gain comprehensive information on the burden of illness due to geographic atrophy (GA).Methods: This cross-sectional study with a retrospective chart review involved patients aged ≥70 years with physician-confirmed bilateral symptomatic GA due to age-related macular degeneration (GA group), as well as patients of similar age with no ophthalmic condition that in the opinion of the investigator affected visual function (non-GA group). Data relating to patients’ current disease status and sociodemographics were self-reported on patient questionnaires at study entry and extracted from patient charts. Historical data on health care resource utilization (HCRU) were also collected via patient questionnaires and retrospective chart review (GA group only). Overall vision-related functioning and quality of life (QoL) were compared between the GA and non-GA groups using the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25) composite and subscales, and change in vision over the past year was assessed using the Global Rating of Change Scale.Results: Vision-related functioning and QoL were poorer in patients with vs without GA (n=137 vs 52), as demonstrated by significantly lower NEI-VFQ-25 composite score (mean, 53.1 vs 84.5 points, respectively; P |
