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Ling Lu,1,* Qiaoyan Liang,2,* Xinyi Zhang,3 Yumeng Xu,3 Dehua Meng,4 Zhaofeng Liang3 1Child Healthcare Department, the Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Peopleâs Republic of China; 2Health Care Department, Peopleâs Liberation Army Navy No. 971 Hospital, Qingdao, Peopleâs Republic of China; 3School of Medicine, Jiangsu University, Zhenjiang, Peopleâs Republic of China; 4Department of Allergy, Dongtai Peopleâs Hospital, Yancheng, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Zhaofeng Liang, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, Peopleâs Republic of China, Email liangzhaofeng@ujs.edu.cn Dehua Meng, Department of Allergy, Dongtai Peopleâs Hospital, 02 Fukang West Road, Yancheng, Jiangsu, 224200, Peopleâs Republic of China, Email 2798184241@qq.comAbstract: Gastric cancer (GC) is one of the most common malignant cancers that seriously affect human health. Autophagy is a highly conserved self-defense mechanism found to plays an important role in the occurrence, progression, drug resistance, and prognosis of GC. Noncoding RNAs (ncRNAs) play a critical role in the occurrence and development of a variety of diseases including GC. In recent years, increasing attention has been given to research on autophagy-related ncRNAs, such as miRNA, lncRNA, and circRNA in GC. Herein, we briefly summarize the roles, functions, and the research progress of autophagy and autophagy-related ncRNAs in GC with a focus on the potential application in GC tumorigenesis, development, prognosis, and drug resistance. We also discussed prospects of clinical application, future research direction, and challenges in future research of autophagy-related ncRNAs.Keywords: gastric cancer, autophagy, noncoding RNA, function |
