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Blake Oberfeld,1,2 Fatemeh Golsoorat Pahlaviani,1 Nathan Hall,1 Henisk Falah-Trzcinski,1 Jonathan Trzcinski,1 Ta Chang,3 David Solá-Del Valle1 1Glaucoma Service, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA, USA; 2Department of Ophthalmology, University of Florida, Gainesville, FL, USA; 3Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, FL, USACorrespondence: David Solá-Del Valle, Glaucoma Service, Massachusetts Eye and Ear Infirmary and Harvard Medical, 243 Charles St, Boston, MA, 02114, USA, Tel +1 617-573-3670, Fax +1 617-573-3707, Email David_Sola-DelValle@MEEI.HARVARD.EDUPurpose: Combining two or more MIGS (cMIGS) promises to be more efficacious than single MIGS (sMIGS). This study compared the efficacy of PEcK, which combines Phacoemulsification (Phaco), Endocyclophotocoagulation (ECP), and Kahook dual blade (KDB), relative to both of its constituent sMIGS, Phaco/ECP (Endo Optiks, NJ) and Phaco/KDB (New World Medical, CA) for the first time.Patients and methods: Data was collected retrospectively from 1833 visits of 271 patients who underwent PEcK, Phaco/ECP, or Phaco/KDB from 2016â 2021 at Massachusetts Eye and Ear. Primary outcomes included Generalized Estimating Equations (GEE) of intraocular pressure (IOP) and medication burden, as well as survival models.Results: Mean preoperative IOP was 17.6 ± 5.0 (SD) mmHg on 3.0 ± 1.4 medications in the PEcK group (n = 128), 17.9 ± 5.1 mmHg on 2.2 ± 1.5 medications in the Phaco/ECP group (n = 78), and 16.1 ± 4.3 mmHg on 0.4 ± 1.0 medications in the Phaco/KDB group (n = 65). For more than 36 months, all procedures resulted in significant patterns of IOP and medication reduction (all p < 0.001), before and after statistical adjustment. The reduction pattern in IOP was significantly different when comparing all groups over time and favored PEcK (p = 0.04), but the reduction pattern in medications was not significantly different (p = 0.11). Procedures did not differ in procedural time (p = 0.18) or in survival to maintain ⥠20% IOP reduction (p = 0.43) without additional medication or procedure. There was a trend toward significant difference in maintaining IOP ⤠goal IOP that favored PEcK over Phaco/ECP after adjustment (p = 0.09).Conclusion: PEcK may confer greater IOP reduction without added procedural time compared to Phaco/ECP and Phaco/KDB in predominantly mild or moderate glaucoma. Further research on cMIGS may benefit from adopting this comparative analysis to constituent MIGS.Keywords: microinvasive glaucoma surgery, cMIGS, generalized estimating equations, GEE, comparative effectiveness, combined efficacy, glaucoma |
