Cerebellar Purkinje cell activity drives motor learning

Autor:	Jennifer L. Raymond, Arunima Kohli, Rhea R. Kimpo, Jacob M Rinaldi, TD Barbara Nguyen-Vu, Hongkui Zeng, Karl Deisseroth
Rok vydání:	2013
Předmět:	Cerebellum education Channelrhodopsin Action Potentials Cerebellar Purkinje cell Mice Transgenic Biology Optogenetics Motor Activity Functional Laterality Article Mice Purkinje Cells Channelrhodopsins Transduction Genetic medicine Animals Learning Motor skill General Neuroscience food and beverages Climbing fiber Dependovirus Luminescent Proteins medicine.anatomical_structure Acoustic Stimulation Gene Expression Regulation Motor Skills Cerebellar cortex Mutation Vestibule Labyrinth Motor learning Neuroscience Photic Stimulation
Zdroj:	Nature neuroscience. 16(12)
ISSN:	1546-1726
Popis:	The climbing fiber input to the cerebellar cortex is thought to provide instructive signals that drive the induction of motor skill learning. We found that optogenetic activation of Purkinje cells, the sole output neurons of the cerebellar cortex, can also drive motor learning in mice. This dual control over the induction of learning by climbing fibers and Purkinje cells can expand the learning capacity of motor circuits.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffffdb37507f2300b7cfaefa3e9c207f https://pubmed.ncbi.nlm.nih.gov/24162651 Zobrazit plný text záznamu Plný text ve formátu PDF