Heterotrisomy recurrence risk: a practical maternal age-dependent approach for excess trisomy 21 risk calculation after a previous autosomal trisomy
| Autor: | Iosifina Stergiotou, Virginia Borobio, M. Grande, Joan Sabrià, Antoni Borrell, Anna Soler |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Pregnancy High-Risk Age dependent Risk Assessment Recurrence risk Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Recurrence Prenatal Diagnosis Screening method Humans Medicine Registries 030219 obstetrics & reproductive medicine business.industry Obstetrics Absolute risk reduction Obstetrics and Gynecology DNA Middle Aged medicine.disease 030104 developmental biology Pediatrics Perinatology and Child Health Female Down Syndrome business Risk assessment Trisomy Maternal Age |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 30:1613-1615 |
| ISSN: | 1476-4954 1476-7058 |
| Popis: | A new maternal age-dependent method to estimate absolute excess risks of trisomy 21, either after a previous trisomy 21 (homotrisomy) or after another trisomy (heterotrisomy), is proposed to be added to the estimated risk by conventional screening methods. Excess risk at term for a subsequent trisomy 21 was calculated from midtrimester risks reported by Morris et al., decreasing from 0.49% at 20 years to 0.01% at 46 years at the index pregnancy. Excess risk after a previous uncommon trisomy was derived from data reported by Warburton et al., decreasing from 0.37% at 20 years to 0.01% at 50 years. |
| Databáze: | OpenAIRE |
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