Identification of Gamma-Butyrolactone in JUUL Liquids
| Autor: | Caroline O. Cobb, Justin L. Poklis, Michelle R. Peace, Alaina K. Holt |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Health
Toxicology and Mutagenesis Electronic Nicotine Delivery Systems Lung injury Toxicology 01 natural sciences Gas Chromatography-Mass Spectrometry Analytical Chemistry Screening analysis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine 4-Butyrolactone Lc ms ms Humans Environmental Chemistry 030212 general & internal medicine Drug enforcement Chemical Health and Safety gamma-Butyrolactone Chromatography Special Issue Chemistry Vaping 010401 analytical chemistry United States 0104 chemical sciences Gas chromatography–mass spectrometry Chromatography Liquid |
| Zdroj: | J Anal Toxicol |
| ISSN: | 1945-2403 0146-4760 |
| Popis: | Gamma-butyrolactone (GBL), a commonly used industrial solvent, is used recreationally as a central nervous system (CNS) depressant and, therefore, is a United States Drug Enforcement Agency List 1 chemical of the Controlled Substances Act. GBL was identified presumptively in the liquid from JUUL Virginia Tobacco flavored pods during routine untargeted screening analysis of e-cigarette products by gas chromatography–mass spectrometry (GC–MS). Methods for the analysis of GBL were developed for GC–MS and liquid chromatography–tandem mass spectrometry (LC–MS-MS) in the liquids and the aerosol generated from the liquid. Three flavors of JUUL pods available at the time of analysis were obtained by direct purchase from the manufacturer, purchase from a local vape shop and submission from a third party. The only liquid flavor to contain GBL was Virginia Tobacco, with an average of 0.37 mg/mL of GBL, and it was detected in the aerosol. Studies evaluating the pharmacological effects of inhaling GBL do not exist; however, a case report of chronic oral GBL ingestion indicates acute lung injury. The identification of GBL in an e-cigarette product purportedly compliant with federal regulation continues to demonstrate public health and public safety concerns. |
| Databáze: | OpenAIRE |
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