Comparison between Roesy and C-13 NMR complexation shifts in deriving the geometry of inclusion compounds: A study on the interaction between hyodeoxycholic acid and 2-hydroxypropyl-beta-cyclodextrin
| Autor: | Gianfranco Salvioli, Maria Angela Vandelli, Flavio Forni, Barbara Ruozi, Luisa Schenetti, Adele Mucci |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Bile acid
medicine.drug_class Chemistry inclusion compounds hyodeoxycholic acid 2-hydroxypropyl-beta-cyclodextrin 1-H and 13-C NMR spectroscopy ROESY NMR Spectroscopy Geometry General Chemistry Nuclear magnetic resonance spectroscopy Carbon-13 NMR Hyodeoxycholic acid Inclusion compound Solvent chemistry.chemical_compound 2-Hydroxypropyl-beta-cyclodextrin 2 hydroxypropyl β cyclodextrin medicine |
| Popis: | The formation and geometry of the hyodeoxycholic acid (HDCA)/2-hydroxypropyl-β-cyclodextrin (HPβCD) complex in methanol-d4 solution was determined through a rotating frame nuclear Overhauser (ROESY) experiment. The reported results confirmed those independently and previously obtained though the use of 13C complexation shifts in the same solvent. The 13C approach, which needs shorter experimental times and is currently used in the study of HPβCD/bile acid systems, was then substantiated. |
| Databáze: | OpenAIRE |
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