Visible-Light Induced Radical Perfluoroalkylation/Cyclization Strategy To Access 2-Perfluoroalkylbenzothiazoles/Benzoselenazoles by EDA Complex
| Autor: | Yufen Zhao, Lingbo Qu, Xiao-Yun Li, Yan Liu, Xiaolan Chen, Xiao-Ceng Liu, Fan-Lin Zeng, Kai Sun, Bing Yu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Organic Chemistry Iodide Nitrogen atmosphere 010402 general chemistry Photochemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Cascade reaction chemistry Irradiation Physical and Theoretical Chemistry Tetrahydrofuran Visible spectrum |
| Zdroj: | Organic letters. 21(11) |
| ISSN: | 1523-7052 |
| Popis: | A novel and practical fluoroalkyl radical-initiated cascade reaction was developed to access diverse 2-fluoroalkylbenzothiazoles by reacting various fluoroalkyl radical sources, including perfluoroalkyl iodide (IC nF2 n+1, n = 3-8, 10), ICF(CF3)2, ICF2COOEt, ICF2CF2Cl, or ICF2CF2Br, tetramethylethane-1,2-diamine (TMEDA), and 2-isocyanoaryl thioethers in tetrahydrofuran under nitrogen atmosphere and blue-light irradiation conditions. Furthermore, this one-pot protocol could well be expanded to access various 2-fluoroalkylbenzoselenazoles starting from (2-isocyanophenyl)(methyl)selane, perfluoroalkyl iodides (IC nF2 n+1, n = 3-8) or ICF2COOEt and TMEDA. |
| Databáze: | OpenAIRE |
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