The Influence of Permeability through Bacterial Porins in Whole-Cell Compound Accumulation
| Autor: | Silvia Acosta-Gutierrez, Matteo Ceccarelli, Igor Bodrenko |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Modern medicine Gram-negative bacteria porins 030106 microbiology RM1-950 Biochemistry Microbiology Article antibiotics 03 medical and health sciences Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics biology Chemistry biology.organism_classification General bacterial porin family 030104 developmental biology Infectious Diseases Porin Biophysics Efflux Therapeutics. Pharmacology Cell envelope permeability Bacterial outer membrane Bacteria |
| Zdroj: | Antibiotics Antibiotics, Vol 10, Iss 635, p 635 (2021) Volume 10 Issue 6 |
| ISSN: | 2079-6382 |
| Popis: | The lack of new drugs for Gram-negative pathogens is a global threat to modern medicine. The complexity of their cell envelope, with an additional outer membrane, hinders internal accumulation and thus, the access of molecules to their targets. Our limited understanding of the molecular basis for compound influx and efflux from these pathogens is a major bottleneck for the discovery of effective antibacterial compounds. Here we analyse the correlation between the whole-cell compound accumulation of ~200 molecules and their predicted porin permeability coefficient (influx), using a recently developed scoring function. We found a strong linear relationship (74%) between the two, confirming porins key in compound uptake in Gram-negative bacteria. The analysis of this unique dataset aids to better understand the molecular descriptors behind whole-cell accumulation and molecular uptake in Gram-negative bacteria. |
| Databáze: | OpenAIRE |
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