Continuous phenobarbital treatment leads to recurrent plantar fibromatosis
| Autor: | Günter Krämer, Heinrich Vogt, Hajo M. Hamer, Adam Strzelczyk |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Connective tissue Fibroma Drug Administration Schedule Foot Diseases Epilepsy medicine Humans Muscle contracture Plantar fibromatosis Neoplasms Connective Tissue business.industry Frozen shoulder medicine.disease Magnetic Resonance Imaging Dermatology Surgery medicine.anatomical_structure Complex regional pain syndrome Neurology Phenobarbital Anticonvulsants Drug Therapy Combination Female Neurology (clinical) Neoplasm Recurrence Local business Primidone medicine.drug |
| Zdroj: | Epilepsia. 49:1965-1968 |
| ISSN: | 1528-1167 0013-9580 |
| DOI: | 10.1111/j.1528-1167.2008.01684.x |
| Popis: | Despite contrary recommendations by expert opinion and international guidelines phenobarbital remains the most widely prescribed anticonvulsant worldwide. Although associated connective tissue disorders were described in a timely way after its introduction, the association between plantar fibromatosis--also called Ledderhose syndrome--and phenobarbital seems not to be well known in general. Our case series uniquely demonstrates that continuous phenobarbital treatment leads to recurrent plantar fibromatosis and may result in long-term disability and numerous unnecessary operations. In general, the association between connective tissue disorders and phenobarbital most prominently appears in adult patients of northern European descent. However, our case series and data from the literature suggest that patient groups less susceptible to connective tissue disorders may as well develop Ledderhose syndrome or other associated syndromes as Dupuytren's contractures, frozen shoulder, Peyronie's disease or complex regional pain syndrome in the course of phenobarbital treatment. |
| Databáze: | OpenAIRE |
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