Changes in volume of various retinal layers over time in early and intermediate age-related macular degeneration
| Autor: | Ali Lamin, Daniel B. Russakoff, Adam M. Dubis, Jonathan D. Oakley, Sobha Sivaprasad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Retinal Ganglion Cells medicine.medical_specialty genetic structures media_common.quotation_subject Visual Acuity Outer plexiform layer Retinal Pigment Epithelium Article Retina 03 medical and health sciences chemistry.chemical_compound Macular Degeneration 0302 clinical medicine Optical coherence tomography Ophthalmology medicine Contrast (vision) Humans Outer nuclear layer media_common Aged Retrospective Studies medicine.diagnostic_test business.industry Retinal Macular degeneration Middle Aged medicine.disease eye diseases Ganglion medicine.anatomical_structure chemistry Inner nuclear layer 030221 ophthalmology & optometry Disease Progression Female sense organs Bruch Membrane business 030217 neurology & neurosurgery Tomography Optical Coherence |
| Popis: | PURPOSE: To evaluate longitudinally volume changes in inner and outer retinal layers in early and intermediate age-related macular degeneration (AMD) compared to healthy control eyes using optical coherence tomography (OCT). METHODS: 71 eyes with AMD and 31 control eyes were imaged at two time points: baseline and after 2 years. Automated OCT layer segmentation was performed using Orion(TM). This software is able to measure volumes of retinal layers with distinct boundaries including Retinal Nerve Fibre Layer (RNFL), Ganglion Cell-Inner Plexiform Layer (GCIPL), Inner Nuclear Layer (INL), Outer Plexiform Layer (OPL), Outer Nuclear Layer (ONL), Photoreceptors (PR) and Retinal Pigment Epithelium–Bruch’s Membrane complex (RPE-BM). The mean retinal layer volumes and volume changes at 2 years were compared between groups. RESULTS: Mean GCIPL and INL volumes were lower, while PR and RPE-BM volumes were higher in AMD eyes than controls at baseline (all P |
| Databáze: | OpenAIRE |
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