A Comparison of Postspace-Flight Orthostatic Intolerance to Vasovagal Syncope and Autonomic Failure and the Potential Use of the Alpha Agonist Midodrine for These Conditions
| Autor: | Mary Ann McElligott, Joseph Jankovic, Stephen Piwinski |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Time Factors Midodrine Orthostatic intolerance Blood Pressure Syncope Hypotension Orthostatic Orthostatic vital signs Heart Rate Heart rate medicine Humans Pharmacology (medical) Plasma Volume Pure autonomic failure Vasovagal syncope Aged Pharmacology business.industry Space Flight medicine.disease Autonomic Nervous System Diseases Vasoconstriction Anesthesia Adjunctive treatment Reflex Female business medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 34:466-471 |
| ISSN: | 0091-2700 |
| DOI: | 10.1002/j.1552-4604.1994.tb04988.x |
| Popis: | After space-flights of less than ten days, orthostatic hypotension upon reentry is characterized by plasma volume depletion that may lead to activation of the Bezold-Jarisch reflex which is also considered to be the mechanism of vasovagal (neurocardiogenic) syncope. For space-flight of longer duration, loss of cardiovascular reflex control may take precedence over volume depletion and thus may have similarities to the orthostatic hypotension seen in patients with autonomic failure secondary to basal ganglial disease and peripheral neuropathies. Midodrine is an alpha-one agonist that produces arterial and venous constriction and leads to a decrease in heart rate by baroreceptor reflexes. The efficacy of Midodrine in successfully treating orthostatic hypotension secondary to autonomic failure has been shown in clinical trials. Midodrine's ability to vasoconstrict without increasing heart rate suggests that it might be a useful treatment for vasovagal syncope since stimulation of the Bezold-Jarisch reflex would be less likely. For post-space flight orthostatic hypotension, midodrine may be a useful adjunctive treatment to the measures currently being used. |
| Databáze: | OpenAIRE |
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