Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis
| Autor: | H Flachs, Kim Brøsen, H E Poulsen, Steffen Loft, Kim Dalhoff, L Ranek, P Wantzin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Phenytoin
Adult Male medicine.medical_specialty Population Sparteine Polymorphism (biology) Complement 3C Pharmacology Biology Hepatitis Polymorphism (computer science) HLA Antigens Internal medicine Metronidazole medicine Humans Mephenytoin HLA antigens education Aged education.field_of_study Polymorphism Genetic Gastroenterology Complement C3 Middle Aged medicine.disease Endocrinology Phenotype Female Polymorphism (genetics) Halothane Chemical and Drug Induced Liver Injury Drug metabolism Antipyrine medicine.drug |
| Zdroj: | Ranek, L, Dalhoff, K, Poulsen, H E, Brøsen, K, Flachs, H, Loft, S & Wantzin, P 1993, ' Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis ', Scandinavian Journal of Gastroenterology, vol. 28, no. 8, pp. 677-680 . https://doi.org/10.3109/00365529309098271 University of Copenhagen Europe PubMed Central |
| DOI: | 10.3109/00365529309098271 |
| Popis: | To test the hypothesis that halothane hepatitis is caused by a combination of altered drug metabolism and an immunoallergic disposition, the metabolism of antipyrine, metronidazole, sparteine, phenytoin, and racemic R- and S-mephenytoin was investigated in seven subjects with previous halothane hepatitis. The HLA tissue types and the complement C3 phenotypes were also determined. The metabolism of antipyrine and metronidazole was within normal range in all subjects, and they were all fast or extensive metabolizers of sparteine, mephenytoin, and phenytoin. HLA tissue types were unremarkable. Five of the seven subjects had complement C3 phenotypes F or FS. In the general population phenotype S is the most common, but the difference in complement C3 phenotypes is not statistically significant (p = 0.07). We conclude, although in a limited number of patients, that subjects with previous halothane hepatitis do not appear to be different from controls with regard to drug metabolism and HLA tissue type. The possibility of a higher frequency of complement C3 phenotype F and FS needs further investigation. |
| Databáze: | OpenAIRE |
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