Nanodiamonds for bioapplications–specific targeting strategies
| Autor: | Takuya F. Segawa, Daiki Terada, Masahiro Shirakawa, Takuya Genjo, Ryuji Igarashi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Biocompatibility
Cell Survival Polymers Surface Properties Static Electricity Biophysics Biocompatible Materials Nanotechnology 02 engineering and technology 010402 general chemistry Fluorescent imaging 01 natural sciences Biochemistry Nanodiamonds Animals Humans Nanodiamond Molecular Biology chemistry.chemical_classification Drug Carriers Chemical treatment Biomolecule Cell Membrane Silicon Dioxide 021001 nanoscience & nanotechnology Lipids Cell function Endocytosis 0104 chemical sciences chemistry Drug delivery Nanoparticles Surface modification 0210 nano-technology |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - General Subjects. 1864:129354 |
| ISSN: | 0304-4165 |
| DOI: | 10.1016/j.bbagen.2019.04.019 |
| Popis: | Background Nanodiamonds (NDs) provide a unique multitasking system for drug delivery and fluorescent imaging in biological environments. Owing to their quantum properties, NDs are expected to be employed as multifunctional probes in the future for the accurate visualization of biophysical parameters such as temperature and magnetic fields. However, the use of NDs for the selective targeting of the biomolecules of interest within a complicated biological system remains a challenge. One of the most promising solutions is the appropriate surface design of NDs based on organic chemistry and biochemistry. The engineered NDs have high biocompatibility and dispersibility in a biological environment and hence undergo cellular uptake through specific pathways. Scope of review This review focuses on the selective targeting of NDs for biomedical and biophysical applications from the viewpoint of ND surface functionalizations and modifications. These pretreatments make possible the specific targeting of biomolecules of interest on or in a cell by NDs via a designed biochemical route. Major conclusions The surface of NDs is covalently or noncovalently modified with silica, polymers, or biomolecules to reshape them, control their size, and enhance the colloidal stability and biomolecular selectivity toward the biomolecules of interest. Electroporation, chemical treatment, injection, or endocytosis are the methods generally adopted to introduce NDs into living cells. The pathway, efficiency, and the cell viability depend on the selected method. General significance In the biomedical field, the surface modification facilitates specific delivery of a drug, leading to a higher therapeutic efficacy. In biophysical applications, the surface modification paves the way for the accurate measurement of physical parameters to gain a better understanding of various cell functions. |
| Databáze: | OpenAIRE |
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