Synthesis and Properties of Mono- or Diamine-Initiated Imidazolium-Based Cationic Polypeptides
| Autor: | Xu Zhang, Fangping Yang, Zikun Yu, Hua Lu, Zuowen Shi, Xiaodan Wang, Shifang Luan, Ying Ling, Haoyu Tang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Polymers and Plastics
Bioengineering 02 engineering and technology Diamines 010402 general chemistry 01 natural sciences Polymerization Biomaterials chemistry.chemical_compound Upper critical solution temperature Diamine Polymer chemistry Materials Chemistry Aqueous solution Chemistry Cationic polymerization Temperature 021001 nanoscience & nanotechnology 0104 chemical sciences Solvent Molecular Weight Amine gas treating 0210 nano-technology Selectivity Peptides |
| Zdroj: | Biomacromolecules. 21(8) |
| ISSN: | 1526-4602 |
| Popis: | A series of cationic polypeptide imidazolium conjugates were prepared by ring-opening polymerization (ROP) of γ-4-(3-chloropropoxycarbonyl)benzyl-L- glutamic acid-based N-carboxyanhydride (CPBLG-NCA) initiated by various mono- or diamine initiators and subsequent side-chain modification with high grafting efficiency. Rapid and controlled ROP was achieved by polymerizing CPBLG-NCA in a dichloromethane/NaHCO3/H2O solvent mixture with the amine initiators. The resulting polypeptides bearing imidazolium iodide pendants showed reversible upper critical solution temperature (UCST)-type thermoresponsive properties in both ethanol and DI water while the polypeptides with tetrafluoroborate counter-anions showed a UCST in phosphate buffer saline (PBS). The cloud point temperature (Tcp) in ethanol and aqueous solutions can be tuned by both molecular weight and the end- or linkage-groups in the main chain. The cationic polypeptides showed good antibacterial activity against Staphylococcus aureus and low hemolysis. Our results provide a facile and rapid ROP strategy to develop new families of stimuli-responsive polypeptides with tunable properties as well as antibacterial polypeptides with optimized selectivity. |
| Databáze: | OpenAIRE |
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