Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age
| Autor: | José Evandro Cunha, Clodis Maria Tavares, Alexandre Casimiro de Macedo, Aparecida Tiemi Nagao-Dias, Juliana Navarro Ueda Yaochite |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) Adolescent 030231 tropical medicine lcsh:QR1-502 Enzyme-Linked Immunosorbent Assay Biology Salivary antibodies lcsh:Microbiology lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Leprosy medicine Humans Family lcsh:RC109-216 Elisa method Child Saliva Index case Mycobacterium leprae Antigens Bacterial Hanseníase Transmission (medicine) biology.organism_classification medicine.disease Antibodies Bacterial Virology 030104 developmental biology Infectious Diseases medicine.anatomical_structure Child Preschool Leprosy Multibacillary Immunology Phenolic glycolipid-1 antigen biology.protein Female Leprosy Paucibacillary Contact Tracing Glycolipids Antibody Respiratory tract |
| Zdroj: | Brazilian Journal of Infectious Diseases, Vol 21, Iss 5, Pp 557-561 (2017) Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC Brazilian Journal of Infectious Diseases, Volume: 21, Issue: 5, Pages: 557-561, Published: OCT 2017 |
| ISSN: | 1413-8670 |
| Popis: | Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4–16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State – Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibody levels. High frequency of IgM positivity strongly suggests active transmission of M. leprae in these communities. We suggest in the present work that salivary anti-PGL IgA and IgM are important biomarkers to be used for identifying communities with probable active transmission of M. leprae. Keywords: Leprosy, Salivary antibodies, Phenolic glycolipid-1 antigen, Mycobacterium leprae |
| Databáze: | OpenAIRE |
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