Frequency of 3’ VNTR Polymorphism in the Dopamine Transporter Gene SLC6A3 in Humans Predisposed to Antisocial Behavior
| Autor: | Lyubomir I. Aftanas, P. N. Men’shanov, N. G. Maksimov, Elena V. Cherepkova |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Gene Expression Theft White People General Biochemistry Genetics and Molecular Biology Russia 03 medical and health sciences 0302 clinical medicine Gene Frequency Polymorphism (computer science) Genotype Humans Genetic Predisposition to Disease 0501 psychology and cognitive sciences Allele 3' Untranslated Regions Gene Alleles Dopamine transporter Genetics Dopamine Plasma Membrane Transport Proteins Polymorphism Genetic biology Prisoners Fraud 05 social sciences Dopaminergic Case-control study Antisocial Personality Disorder General Medicine Middle Aged Variable number tandem repeat Tandem Repeat Sequences Case-Control Studies biology.protein Homicide 030217 neurology & neurosurgery 050104 developmental & child psychology |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 162:82-85 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-016-3551-7 |
| Popis: | Predisposition to antisocial behavior can be related to the presence of certain polymorphic variants of genes encoding dopaminergic system proteins. We studied the frequencies of allele variants and genotypes of variable number tandem repeat polymorphism in 3' untranslated region (3' VTNR) of the dopaminergic transporter SLC6A3 gene in Caucasian men committed socially dangerous violent and non-violent crimes. Alleles with 9 and 10 repeats were most frequent in both the control group and group of men predisposed to antisocial behavior. At the same time, the 10/10 genotype was more frequently observed in the group of men prone to antisocial non-violent behavior. Hence, the presence of certain variants of 3' VTNR polymorphism of SLC6A3 gene in men is associated with predisposition to certain forms of antisocial behavior. |
| Databáze: | OpenAIRE |
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