The Level of Squamous Cell Carcinoma Antigen and Lymph Node Metastasis in Locally Advanced Cervical Cancer
| Autor: | Arb-Aroon Lertkhachonsuk, Sasivimol Rattanasiri, Nathpong Israngura Na Ayudhya, Chuenkamon Charakorn, Navamol Lekskul |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Epidemiology Uterine Cervical Neoplasms Metastasis Carcinoma Adenosquamous Antigens Neoplasm Paraaortic lymph nodes Internal medicine Para-Aortic Bodies medicine Humans Pelvic Neoplasms Lymph node Cervix Serpins Neoplasm Staging Immunoassay Cervical cancer Receiver operating characteristic Parametrial business.industry Public Health Environmental and Occupational Health Prognosis medicine.disease stomatognathic diseases medicine.anatomical_structure Lymphatic Metastasis Carcinoma Squamous Cell Female business Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 16:4719-4722 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2015.16.11.4719 |
| Popis: | Background: This study aimed to determine the utility and a cut-off level of serum squamous cell carcinoma antigen (SCC-Ag) to predict lymph node metastasis in locally advanced cervical cancer cases. We also investigated the correlation between SCC-Ag level and lymph node status. Materials and Methods: From June 2009 to June 2014, 232 patients with cervical cancer stage IB2-IVA, who were treated at Ramathibodi Hospital, were recruited. Receiver operating characteristic (ROC) curves were used to identify the best cut-off point of SCC-Ag level to predict lymph node metastasis. Quantile regression was performed to evaluate the correlation between SCC-Ag levels and pelvic lymph node metastasis, paraaortic lymph node metastasis, and parametrial involvement as well as tumor size. Results: Pelvic lymph node metastasis and paraaortic lymph node metastasis were diagnosed in 46.6% and 20.1% of the patients, respectively. The median SCC-Ag level was 6 ng/mL (range, 0.5 to 464.6 ng/ mL). The areas under ROC curves between SCC-Ag level and pelvic lymph node metastasis, paraaotic lymph node metastasis, parametrial involvements were low. SCC-Ag level was significantly correlated with paraaortic lymph node status (p=0.045) but not with pelvic lymph node status and parametrial involvement. SCC-Ag level was also related to the tumor diameter (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|