Language skills as a predictor of cognitive decline in adults with Down syndrome
| Autor: | Christy Hom, H. Diana Rosas, Casey L. Evans, Florence Lai, Ira T. Lott, Margaret B. Pulsifer, Sharon J. Krinsky-McHale, Nicole Schupf, Jiyang Wen, Wayne Silverman |
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| Rok vydání: | 2020 |
| Předmět: |
Down syndrome
Aging language skills Intellectual and Developmental Disabilities (IDD) lcsh:Geriatrics Neurodegenerative Article lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine mild cognitive impairment Quality of life Clinical Research Behavioral and Social Science medicine Acquired Cognitive Impairment Genetics Dementia Verbal fluency test Cognitive decline lcsh:Neurology. Diseases of the nervous system 030304 developmental biology semantic verbal fluency 0303 health sciences Neuropsychology Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Cognition Alzheimer's disease medicine.disease Brain Disorders Psychiatry and Mental health lcsh:RC952-954.6 Boston Naming Test Alzheimers disease Neurological Neurology (clinical) Psychology 030217 neurology & neurosurgery Clinical psychology Research Article |
| Zdroj: | Alzheimer's & dementia (Amsterdam, Netherlands), vol 12, iss 1 Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020) Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring |
| Popis: | Author(s): Pulsifer, Margaret B; Evans, Casey L; Hom, Christy; Krinsky-McHale, Sharon J; Silverman, Wayne; Lai, Florence; Lott, Ira; Schupf, Nicole; Wen, Jiyang; Rosas, H Diana | Abstract: IntroductionAdults with Down syndrome (DS) are at high risk for early onset Alzheimer's disease (AD), characterized by a progressive decline in multiple cognitive domains including language, which can impact social interactions, behavior, and quality of life. This cross-sectional study examined the relationship between language skills and dementia.MethodsA total of 168 adults with DS (mean age = 51.4 years) received neuropsychological assessments, including Vineland Communication Domain, McCarthy Verbal Fluency, and Boston Naming Test, and were categorized in one of three clinical groups: cognitively stable (CS, 57.8%); mild cognitive impairment (MCI-DS, 22.6%); and probable/definite dementia (AD-DS, 19.6%). Logistic regression was used to determine how well language measures predict group status.ResultsVineland Communication, particularly receptive language, was a significant predictor of MCI-DS. Semantic verbal fluency was the strongest predictor of AD-DS.DiscussionAssessment of language skills can aid in the identification of dementia in adults with DS. Clinically, indications of emerging language problems should warrant further evaluation and monitoring. |
| Databáze: | OpenAIRE |
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