Synthetic Studies of Vitamin D Analogues. XIV. Synthesis and Calcium Regulating Activity of Vitamin D3 Analogues Bearing a Hydroxyalkoxy Group at the 2.BETA.-Position
Autor: | Kiyoshige Ochi, Eigoro Murayama, Noboru Kubodera, Katsuhito Miyamoto, Hiroyoshi Watanabe |
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Rok vydání: | 1993 |
Předmět: |
Male
Vitamin Magnetic Resonance Spectroscopy Stereochemistry medicine.medical_treatment Administration Oral chemistry.chemical_element Calcium Mass Spectrometry Steroid Rats Sprague-Dawley chemistry.chemical_compound Calcitriol Drug Discovery Vitamin D and neurology medicine Animals Potency Cholecalciferol Chemistry Biological activity General Chemistry General Medicine Metabolism Vitamin D Deficiency Rats Calcium Dietary Spectrophotometry Ultraviolet |
Zdroj: | Chemical and Pharmaceutical Bulletin. 41:1111-1113 |
ISSN: | 1347-5223 0009-2363 |
Popis: | Four vitamin D3 analogues (7a, 7b, 7c and 7d) bearing a hydroxyalkoxy group at the 2 beta-position were synthesized from the alpha-epoxide (5). The C-3 analogue (7b) showed the highest potency for elevating plasma calcium levels in rats. Furthermore, the 25-hydroxylated C-3 analogue (ED-71) (3), prepared from the 25-hydroxylated alpha-epoxide (9), significantly increased plasma calcium to levels much higher than those in rats administered 1 alpha,25-(OH)2-D3 (1). |
Databáze: | OpenAIRE |
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