Prognosis of Non-Small Cell Lung Cancer with Synchronous Brain Metastases Treated with Gamma Knife Radiosurgery
| Autor: | Kwan Park, Jun-O Park, Jhin Gook Kim, Jong Hyun Kim, Jung-Il Lee, Do-Hyun Nam, Keunchil Park, Doo-Sik Kong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Systemic disease Lung Neoplasms Time Factors medicine.medical_treatment Disease Radiosurgery Internal medicine Carcinoma Non-Small-Cell Lung medicine Humans Neoplasm Metastasis Lung cancer Aged Aged 80 and over Chemotherapy Performance status business.industry Brain Neoplasms General Medicine Middle Aged medicine.disease Prognosis Primary tumor Radiation therapy Treatment Outcome Original Article Female business |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | The clinical outcome and prognostic factors of patients with synchronous brain metastases from non-small cell lung cancer (NSCLC) who were treated with gamma knife radiosurgery (GKS) were analyzed. A total of 35 patients with NSCLC underwent GKS as an initial treatment for metastatic brain lesions of synchronous onset. The period of survival and various prognostic factors such as age, gender, performance status, multiplicity of the brain lesions, intracranial tumor volume, and extent of the primary tumor were analyzed. The overall median survival time for this series was 12 months (range 0.75 to 43 months) from the diagnosis. Of the 21 patients who were no longer alive at the conclusion of this study, only 7 (33.3%) died of neurological causes. Multivariate analysis of these data revealed that N stage, whole-brain radiotherapy (WBRT), and chemotherapy were significant predictors for survival (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|