Treatment of Gastroesophageal Reflux Disease: Endoscopic Aspects
| Autor: | Julius Špičák |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Injections Prosthesis Implantation Animals Humans Medicine Esophagus business.industry General surgery Suture Techniques Gastroenterology Heartburn General Medicine medicine.disease Dysphagia Clinical trial medicine.anatomical_structure Regurgitation (digestion) Catheter Ablation Gastroesophageal Reflux GERD Esophagoscopy medicine.symptom business Esophagitis Stretta procedure |
| Zdroj: | Digestive Diseases. 25:183-187 |
| ISSN: | 1421-9875 0257-2753 |
| DOI: | 10.1159/000103882 |
| Popis: | Gastroesophageal reflux disease (GERD) is a very common chronic disorder manifesting itself as heartburn, regurgitation, or dysphagia, possibly leading to esophagitis, Barrett’s esophagus and adenocarcinoma, and has a major impact on the patient’s quality of life. Both medical treatment and surgery are well-established methods with several limitations. Recently, three types of endoscopic methods in several modifications have been developed: (1) Radiofrequency therapy (Stretta procedure) is available both in Europe and USA and more than 5,000 patients have been treated to date. (2) Injection therapy requires the injection of bulking agents or implantation of bioprosthesis into the lower esophageal sphincter (LES) zone. Both Enteryx was withdrawn from the market in 2005, and Gatekeeper was suspended before FDA approval. (3) Suturing/plication therapy is based on the plication at the level of the LES, and most of all techniques resemble the principle of surgical treatment. Despite sophisticated technologies and promising short-term results, all these techniques are associated with inconsistencies, controversies, and relevant adverse affects. According to current practice, use of endoscopic methods is justifiable only as part of clinical trials. Many aspects, including commercial ones, will influence future developments in this area, which are difficult to predict. |
| Databáze: | OpenAIRE |
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