A double-blind crossover study comparing tolmetin and indomethacin in the treatment of rheumatoid arthritis

Autor:	D. N. Golding, C. E. Steele, Abigail Freeman
Rok vydání:	1977
Předmět:	Adult Male business.industry Indomethacin Arthritis General Medicine Middle Aged medicine.disease Placebo Crossover study Treatment period Arthritis Rheumatoid Double blind Grip strength Double-Blind Method Anesthesia Rheumatoid arthritis medicine Humans Tolmetin Female business Aged medicine.drug
Zdroj:	Current Medical Research and Opinion. 5:262-265
ISSN:	1473-4877 0300-7995
DOI:	10.1185/03007997709110176
Popis:	SummaryA double-blind crossover trial was carried out in 21 patients with classical or definite rheumatoid arthritis to compare the efficacy of tolmetin (1600 mgper day) with that of indomethacin (100 mg per day) and placebo. After a 1-week wash-out period on paracetamol, patients were treated for 1 week with either tolmetin or indomethacin and then for 1 week on placebo before being crossed over to the alternative drug for a final week. At the end of each treatment period, assessments were made of the severity of morning stiffness and pain, articular index, digital joint size, grip strength, andpatients assessment of well-being and treatment period preference. Tolmetin and indomethacin showed comparable efficacy, and both proved significantly superior to placebo and paracetamol in all parameters, except digital joint size and patients' well-being. One patient was withdrawn because of side-effects on both drugs, but few other side-effects were reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe44053e27c9b72a1c631a848737ce2 https://doi.org/10.1185/03007997709110176 Zobrazit plný text záznamu