Decline of HPV infections in Scandinavian cervical screening populations after introduction of HPV vaccination programs
Autor: | Mari Nygård, Bo T. Hansen, Kai Li Liaw, Joakim Dillner, Maria Hortlund, Christian Munk, Susanne K. Kjaer, Camilla Lagheden |
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Rok vydání: | 2018 |
Předmět: |
Adult
medicine.medical_specialty Adolescent Genotype Denmark Population Uterine Cervical Neoplasms Young Adult 03 medical and health sciences 0302 clinical medicine Human Papillomavirus Recombinant Vaccine Quadrivalent Types 6 11 16 18 Prevalence medicine Humans 030212 general & internal medicine Human papillomavirus Child education Papillomaviridae Early Detection of Cancer Aged Aged 80 and over Sweden Human papillomavirus 16 education.field_of_study Cervical screening General Veterinary General Immunology and Microbiology Hpv types Immunization Programs Norway Obstetrics business.industry Papillomavirus Infections Public Health Environmental and Occupational Health HPV infection virus diseases Hpv vaccination Middle Aged medicine.disease female genital diseases and pregnancy complications Vaccination Infectious Diseases 030220 oncology & carcinogenesis Liquid-based cytology Molecular Medicine Female business |
Zdroj: | Vaccine. 36:3820-3829 |
ISSN: | 0264-410X |
Popis: | To monitor the changes in prevalence of human papillomavirus (HPV) infections in women50 years of age, participating in cervical screening programs of Denmark, Norway, and Sweden, before and after introduction of quadrivalent HPV (qHPV) vaccination.Liquid-based cytology samples were collected from 6538 women who attended cervical screening in Denmark, Norway, and Sweden in 2006-2008 and from 6332 similarly enrolled women in 2012-2013. Denmark started organized qHPV vaccination in 2008, Norway in 2009, and Sweden in 2012. All HPV testing and genotyping was performed using identical enrollment and analysis methods, by accredited general primer polymerase chain reaction methods with typing using the Luminex system.Overall HPV positivity declined slightly from 36.5% in 2006-2008 to 34.5% in 2012-2013. The decline was most pronounced among women 18-26 years of age: from 54.4% to 48.1% (P 0.001). The decline was substantial for vaccine HPV types (HPV6/11/16/18: decline from 22.3% to 16.6%; P 0.001) and was seen for both low-risk vaccine types (HPV6/11 declined from 5.0% to 2.5%) and high-risk vaccine types (HPV16/18 declined from 18.9% to 14.9%). Among women 27-50 years of age, there was no change between the time periods (22.5% and 21.6%, respectively). The significant decline in the younger age group was different in the 3 countries.This population-based study enrolling12,000 women participating in cervical screening in the 3 Nordic countries before and after introduction of organized qHPV vaccination demonstrated a marked decline in HPV infection in the younger population in the 2 countries where qHPV vaccination programs started in 2008-2009, suggesting that organized HPV vaccination programs resulted in a decrease of HPV types circulating in the general population. |
Databáze: | OpenAIRE |
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