Decline of HPV infections in Scandinavian cervical screening populations after introduction of HPV vaccination programs

Autor: Mari Nygård, Bo T. Hansen, Kai Li Liaw, Joakim Dillner, Maria Hortlund, Christian Munk, Susanne K. Kjaer, Camilla Lagheden
Rok vydání: 2018
Předmět:
Adult
medicine.medical_specialty
Adolescent
Genotype
Denmark
Population
Uterine Cervical Neoplasms
Young Adult
03 medical and health sciences
0302 clinical medicine
Human Papillomavirus Recombinant Vaccine Quadrivalent
Types 6
11
16
18
Prevalence
medicine
Humans
030212 general & internal medicine
Human papillomavirus
Child
education
Papillomaviridae
Early Detection of Cancer
Aged
Aged
80 and over
Sweden
Human papillomavirus 16
education.field_of_study
Cervical screening
General Veterinary
General Immunology and Microbiology
Hpv types
Immunization Programs
Norway
Obstetrics
business.industry
Papillomavirus Infections
Public Health
Environmental and Occupational Health
HPV infection
virus diseases
Hpv vaccination
Middle Aged
medicine.disease
female genital diseases and pregnancy complications
Vaccination
Infectious Diseases
030220 oncology & carcinogenesis
Liquid-based cytology
Molecular Medicine
Female
business
Zdroj: Vaccine. 36:3820-3829
ISSN: 0264-410X
Popis: To monitor the changes in prevalence of human papillomavirus (HPV) infections in women50 years of age, participating in cervical screening programs of Denmark, Norway, and Sweden, before and after introduction of quadrivalent HPV (qHPV) vaccination.Liquid-based cytology samples were collected from 6538 women who attended cervical screening in Denmark, Norway, and Sweden in 2006-2008 and from 6332 similarly enrolled women in 2012-2013. Denmark started organized qHPV vaccination in 2008, Norway in 2009, and Sweden in 2012. All HPV testing and genotyping was performed using identical enrollment and analysis methods, by accredited general primer polymerase chain reaction methods with typing using the Luminex system.Overall HPV positivity declined slightly from 36.5% in 2006-2008 to 34.5% in 2012-2013. The decline was most pronounced among women 18-26 years of age: from 54.4% to 48.1% (P 0.001). The decline was substantial for vaccine HPV types (HPV6/11/16/18: decline from 22.3% to 16.6%; P 0.001) and was seen for both low-risk vaccine types (HPV6/11 declined from 5.0% to 2.5%) and high-risk vaccine types (HPV16/18 declined from 18.9% to 14.9%). Among women 27-50 years of age, there was no change between the time periods (22.5% and 21.6%, respectively). The significant decline in the younger age group was different in the 3 countries.This population-based study enrolling12,000 women participating in cervical screening in the 3 Nordic countries before and after introduction of organized qHPV vaccination demonstrated a marked decline in HPV infection in the younger population in the 2 countries where qHPV vaccination programs started in 2008-2009, suggesting that organized HPV vaccination programs resulted in a decrease of HPV types circulating in the general population.
Databáze: OpenAIRE
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