Maintenance of HIV-Specific CD4+ T Cell Help Distinguishes HIV-2 from HIV-1 Infection
| Autor: | Tao Dong, Toyin Togun, Hilton Whittle, Samuel J. McConkey, Assan Jaye, Melody G. Duvall, M A B van der Sande, Don Jeffries, Andrew J. McMichael, Sarah Rowland-Jones, Daniel C. Douek, Richard A. Koup, Abraham Alabi, Jason M. Brenchley |
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| Rok vydání: | 2006 |
| Předmět: |
CD4-Positive T-Lymphocytes
Intracellular Fluid Interleukin 2 T cell Cellular differentiation Immunology Epitopes T-Lymphocyte Gene Products gag HIV Infections CD8-Positive T-Lymphocytes Biology HIV Long-Term Survivors Interferon-gamma Interleukin 21 CD57 Antigens medicine Humans Immunology and Allergy Cytotoxic T cell Interferon gamma Cell Proliferation Cell growth virus diseases Cell Differentiation Virology CD4 Lymphocyte Count Cross-Sectional Studies medicine.anatomical_structure HIV-2 Disease Progression HIV-1 Interleukin-2 CD8 medicine.drug |
| Zdroj: | The Journal of Immunology. 176:6973-6981 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Unlike HIV-1-infected people, most HIV-2-infected subjects maintain a healthy CD4+ T cell count and a strong HIV-specific CD4+ T cell response. To define the cellular immunological correlates of good prognosis in HIV-2 infection, we conducted a cross-sectional study of HIV Gag-specific T cell function in HIV-1- and HIV-2-infected Gambians. Using cytokine flow cytometry and lymphoproliferation assays, we show that HIV-specific CD4+ T cells from HIV-2-infected individuals maintained proliferative capacity, were not terminally differentiated (CD57−), and more frequently produced IFN-γ or IL-2 than CD4+ T cells from HIV-1-infected donors. Polyfunctional (IFN-γ+/IL-2+) HIV-specific CD4+ T cells were found exclusively in HIV-2+ donors. The disparity in CD4+ T cell responses between asymptomatic HIV-1- and HIV-2-infected subjects was not associated with differences in the proliferative capacity of HIV-specific CD8+ T cells. This study demonstrates that HIV-2-infected donors have a well-preserved and functionally heterogeneous HIV-specific memory CD4+ T cell response that is associated with delayed disease progression in the majority of infected people. |
| Databáze: | OpenAIRE |
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