Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12
| Autor: | Almut Jentsch, Heiko Till, Andreas Müller, Henning Petermann, Horst S. Fink, Uwe Till, Falko H. Herrmann, Peter Röhl, Klaus Bellstedt, Reiner Riezler, Rüdiger Vollandt, Ulrich Sliwka, Dietmar Plonné |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Hyperhomocysteinemia Homocysteine Placebo Gastroenterology Brain Ischemia chemistry.chemical_compound Folic Acid Double-Blind Method Risk Factors Internal medicine medicine Humans Vitamin B12 Cyanocobalamin Risk factor Aged Ultrasonography business.industry Middle Aged Intracranial Arteriosclerosis medicine.disease Vitamin B 6 Vitamin B 12 B vitamins Carotid Arteries Endocrinology chemistry Intima-media thickness cardiovascular system Female Tunica Intima Tunica Media Cardiology and Cardiovascular Medicine business |
| Zdroj: | Atherosclerosis. 181:131-135 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2004.12.043 |
| Popis: | Hyperhomocysteinemia is associated with atherosclerotic risk. Although vitamins can lower homocysteine (Hcy), information about effects on atherosclerosis is scarce.We used carotid intima-media thickness (IMT) as an accepted marker of atherosclerotic changes. Fifty patients (60 +/- 8 years) with IMTor =1 mm were included. In a double blind, randomized trial they received daily 2.5 mg folic acid, 25 mg Vitamin B6, and 0.5mg Vitamin B12 or placebo for 1 year.In the treatment group, Hcy decreased from 10.50 +/- 3.93 to 6.56 +/- 1.53 micromol/l (P0.0001), whereas it remained unchanged in the placebo group (10.76 +/- 2.36 versus 10.45+/-3.30 micromol/l). IMT decreased from 1.50 +/- 0.44 to 1.42 +/- 0.48 mm (P = 0.034) in the treatment group, whereas it increased from 1.47 +/- 0.57 to 1.54 +/- 0.71 mm in the placebo group. The mean individual changes of IMT between both groups differed significantly (-0.08 +/- 0.17 versus 0.07 +/- 0.25 mm, P = 0.019). Multiple regression analysis revealed that the observed effect on IMT depended only on medication.Vitamin supplementation significantly reduces IMT in patients at risk. This effect is independent of Hcy concentration. |
| Databáze: | OpenAIRE |
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