CATTLE (BOS TAURUS) RESIST CHRONIC WASTING DISEASE FOLLOWING ORAL INOCULATION CHALLENGE OR TEN YEARS' NATURAL EXPOSURE IN CONTAMINATED ENVIRONMENTS
| Autor: | Michael W. Miller, Jean E. Jewell, Donal O’Toole, Elizabeth S. Williams, Terry J. Kreeger |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Veterinary medicine 040301 veterinary sciences animal diseases Biology Odocoileus Brain homogenate 0403 veterinary science 03 medical and health sciences Domestic cattle Species Specificity medicine Animals Neurologic disease Ecology Evolution Behavior and Systematics Ecology Inoculation Deer Environmental Exposure 04 agricultural and veterinary sciences Chronic wasting disease biology.organism_classification medicine.disease 030104 developmental biology Wasting Disease Chronic Enzootic Cattle Disease Susceptibility Cervus canadensis |
| Zdroj: | Journal of Wildlife Diseases. 54:460 |
| ISSN: | 0090-3558 |
| DOI: | 10.7589/2017-12-299 |
| Popis: | We conducted a 10-yr study to establish whether chronic wasting disease (CWD) was readily transmissible to domestic cattle ( Bos taurus) following oral inoculation or by cohousing cattle with captive cervids in outdoor research facilities where CWD was enzootic. Calves ( n=12) were challenged orally on one occasion using brain homogenate derived from CWD-infected mule deer ( Odocoileus hemionus). Five uninoculated cattle served as unchallenged controls. Two other groups of cattle ( n=10-11/group) were housed outdoors for 10 yr in captive cervid research facilities. The environmentally challenged cattle were exposed to CWD-associated prions through common paddocks, feed, and water and via direct daily contact with known and potentially infected mule deer or wapiti ( Cervus canadensis) throughout the decade-long study period. None of the exposed cattle developed neurologic disease during the study. We euthanized cattle surviving to 10 yr postchallenge and examined all for lesions or disease-associated prion protein (PrP |
| Databáze: | OpenAIRE |
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