Correlation between HER2 Expression and Clinicopathological Features of Breast Cancer: A Cross- Sectional Study in Vietnam
| Autor: | Quynh Anh Nguyen Phan, Bao Song Nguyen Tran, Quoc Huy Nguyen Vu, Ai Phuong Hoang Thi, Thuan Dang Cong, Tung Nguyen Thanh |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Oncology medicine.medical_specialty Receptor ErbB-2 Estrogen receptor Breast Neoplasms DISH 03 medical and health sciences Breast cancer 0302 clinical medicine HER2 Internal medicine Progesterone receptor Biomarkers Tumor medicine Humans Neoplasm Invasiveness skin and connective tissue diseases Lymph node Oncogene business.industry Gene Amplification General Medicine Middle Aged Prognosis medicine.disease Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure Vietnam Invasive carcinoma of no special type Lymphatic Metastasis 030220 oncology & carcinogenesis immunohistochemistry Nottingham Prognostic Index Immunohistochemistry Female business clinicopathological features Follow-Up Studies Research Article |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| DOI: | 10.31557/apjcp.2020.21.4.1135 |
| Popis: | Background HER2 is the target of the therapeutic agents which are used to treat HER2-positive breast cancer. Reports have shown that the HER2 oncogene expression and its association with clinicopathological factors remain unclear in breast cancer (BC) patients. This study aimed to determine the correlation between HER2 expression and clinicalpathological characteristics of breast cancer in Vietnamese women. Methods Between June 2016 and August 2018, paraffin-embedded specimens from 237 patients with primary invasive breast carcinoma in Hue University Hospital and Hue Center Hospital, Hue city, Vietnam were examined for pathological features. The gene expression of HER2, ER, PR and Ki-67 were determined by immunohistochemistry (IHC). The gene amplification of Her2 was assessed by using Dual color in situ hybridization (DISH). Results The most frequent histological type was invasive carcinoma of no special type (NST) with 77.35%, the highest percentage of patients with Grade II was detected (59.36%), tumor size > 2 cm accounted for 71.31% of cases, Lymph node metastases were available in 57.86% cases. Most patients were diagnosed at stage II (59.18%). The majority of patients were classified as moderate Nottingham prognostic index (54.9%). Estrogen receptor and Progesterone receptor were positive in 53.16% and 50.63%, respectively. 76.37% of cases were in high expression group of Ki-67 (≥14%). HER2 IHC 2+, 3+ were accounted for 28.69% and HER2 gene amplification was detected in 31% cases. HER2 gene amplification and/or overexpression was significantly associated with cell proliferation index Ki67. Furthermore, HER2 gene expression tended to be more frequently found in tumors with large tumor size, high grade, high stage and high Nottingham prognostic index and confirmed their prognostic independent role. Conclusions Our data indicated that HER2 gene expression was significantly correlated with cell proliferation index Ki67, but not significantly associated with another clinicopathological factors in breast cancer of Vietnamese women. . |
| Databáze: | OpenAIRE |
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