The management, outcome, and postpartum disease course of 41 pregnancies in 20 women with polycythemia vera
| Autor: | Tatjana Becker, Johannes Bernhardt, Karlo Huenerbein, Kai Wille, Martin Griesshammer, Parvis Sadjadian, Vera Kolatzki |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Hemorrhage Abortion Disease course Miscarriage 03 medical and health sciences Young Adult 0302 clinical medicine Polycythemia vera Pregnancy medicine Humans Polycythemia Vera Retrospective Studies Fetus Essential thrombocythemia Obstetrics business.industry Pregnancy Outcome Hematology General Medicine Heparin Low-Molecular-Weight medicine.disease Abortion Spontaneous Pregnancy Complications Treatment Outcome 030220 oncology & carcinogenesis Female Live birth business 030215 immunology Thrombocythemia Essential |
| Zdroj: | European journal of haematologyREFERENCES. 107(1) |
| ISSN: | 1600-0609 |
| Popis: | OBJECTIVES Pregnancies in women with polycythemia vera (PV) are associated with an increased risk of PV-related maternal complications and often result in miscarriage. Recommendations for the management of PV pregnancies are mainly based on studies with a small number of patients. A correlation between pregnancy outcome and postpartum course has been reported for essential thrombocythemia, but corresponding data for PV are lacking so far. METHODS In 41 PV pregnancies, the pregnancy outcome, the use of PV-specific therapies (ie, acetylsalicylic acid, low-molecular weight heparin and/or interferon-alpha), and the postpartum PV course were investigated. RESULTS A live birth rate of 51.2% (21/41 pregnancies) was observed. 43.9% of pregnancies ended in spontaneous abortion and 4.9% in stillbirth. A significantly increased live birth rate occurred in pregnancies with PV-specific therapies compared to standard antenatal care (69.0% vs. 8.3%; P |
| Databáze: | OpenAIRE |
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