1,3-Bis (2-chloroethyl)-1-nitrosourea: Effects on advanced ovarian carcinoma
| Autor: | Alan King, Thomas E. Godfrey, Robert Rentschler |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Adult
Blood Platelets Oncology Nitrosourea medicine.medical_specialty Cystadenocarcinoma Drug Resistance Urology Drug resistance chemistry.chemical_compound Ovarian carcinoma Internal medicine Leukocytes medicine Humans Aged Ovarian Neoplasms Postoperative Care Carmustine business.industry Obstetrics and Gynecology Cancer Middle Aged medicine.disease chemistry Total dose Female Ovarian cancer business medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 115:576-577 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/0002-9378(73)90412-2 |
| Popis: | 13-bis(2-chloroethyl)-1-nitrosourea (BCNU) was given at 1 hour iv infusions to 11 consecutive patients with advanced ovarian cystadenocarcinoma resistant to alkylating agents. 10 received 300 mg over 3 days and 4 received 100 mg biweekly for 2-10 weeks average total dose 252 mg per square meter. There were no responses to treatment but no drug related deaths. With 95% confidence limits 0-28% of such patients would respond to BCNU at the doses used. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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