The effect of penicillin on the release of γ-aminobutyric acid from cerebral cortex slices
| Autor: | J. Young, Robert W. P. Cutler |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.drug_class
Endogeny Pharmacology Inhibitory postsynaptic potential Aminobutyric acid Glutamates Culture Techniques medicine Animals Amino Acids Molecular Biology gamma-Aminobutyric Acid Cerebral Cortex chemistry.chemical_classification Veratridine Dose-Response Relationship Drug General Neuroscience Penicillin G Rats Amino acid Penicillin medicine.anatomical_structure nervous system Biochemistry chemistry Cerebral cortex Potassium Calcium Depressant Neurology (clinical) Free nerve ending Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 170:157-163 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(79)90947-8 |
| Popis: | Penicillin is known to block the depressant action of GABA on cortical and spinal neurons. In this study we examined the effect of penicillin on the release of endogenous amino acids from rat cerebral cortex slices. The principal finding was that penicillin blocked the potassium-stimulated release of GABA, a calcium-dependent process. It did not block the veratridine-stimulated release of GABA, a calcium-independent process. It did not affect the release of other putative transmitter amino acids. Inhibition of GABA release from nerve endings may explain in part the ability of penicillin to depress synaptic inhibitory mechanisms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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