CIRCULATORY EFFECTS OF ATROPINE IN PATIENTS ANAESTHETIZED WITH NITROUS OXIDE AND TUBOCURARINE
| Autor: | B. R. Kennedy, J. V. Farman |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Artificial ventilation
Adult Atropine Male Tachycardia medicine.medical_specialty Mean arterial pressure Cardiac output medicine.medical_treatment Nitrous Oxide Tubocurarine Blood Pressure pCO2 Blood Circulation Time Heart Rate Internal medicine Heart rate medicine Humans Cardiac Output business.industry Heart Stroke volume Middle Aged Respiration Artificial Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia Circulatory system Blood Circulation Cardiology Vascular resistance Female Vascular Resistance Halothane medicine.symptom Anesthesia Inhalation business medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 40:876-884 |
| ISSN: | 0007-0912 |
| Popis: | SUMMARY Atropine was given intravenously in a dose of 0.012 mg/kg to ten artificially ventilated patients anaesthetized with nitrous oxide and tubocurarine. The heart rate increased from a mean of 68 to a mean of 96 beats/min. This was accompanied by a 31 per cent increase in cardiac output and a 12 per cent rise in mean arterial pressure. There was no significant change in stroke volume or left ventricular stroke work. Total peripheral resistance fell by 14 per cent and circulation time by 22 per cent. Use of 0.5 per cent halothane in the inspired mixture in five cases resulted in smaller increases in heart rate and cardiac output than were seen in the other five. The results were compared with those in an earlier report in which the patients breathed spontaneously during halothane-nitrous oxide anaesthesia (Farman, 1967). The response to atropine depends not only on the effect of the drug on the heart, but also on the control state of the circulation, both of which are heavily influenced by other anaesthetic drugs, by the arterial Pco2 and by the mechanical effect of artificial ventilation. |
| Databáze: | OpenAIRE |
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