Fantastic IgA plasma cells and where to find them
| Autor: | Alexandra Florescu, Angela A. Wang, Baweleta Isho, Jennifer L. Gommerman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Lamina propria Effector Plasma Cells Immunology Inflammation Biology Immunoglobulin A Peyer's Patches 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system medicine.anatomical_structure medicine Immunology and Allergy Lymph Nodes Intestinal Mucosa medicine.symptom Homeostasis 030215 immunology |
| Zdroj: | Immunological Reviews. 303:119-137 |
| ISSN: | 1600-065X 0105-2896 |
| DOI: | 10.1111/imr.12980 |
| Popis: | IgA is produced in large quantities at mucosal surfaces by IgA+ plasma cells (PC), protecting the host from pathogens, and restricting commensal access to the subepithelium. It is becoming increasingly appreciated that IgA+ PC are not constrained to mucosal barrier sites. Rather, IgA+ PC may leave these sites where they provide both host defense and immunoregulatory function. In this review, we will outline how IgA+ PC are generated within the mucosae and how they subsequently migrate to their "classical" effector site, the gut lamina propria. From there we provide examples of IgA+ PC displacement from the gut to other parts of the body, referencing examples during homeostasis and inflammation. Lastly, we will speculate on mechanisms of IgA+ PC displacement to other tissues. Our aim is to provide a new perspective on how IgA+ PC are truly fantastic beasts of the immune system and identify new places to find them. |
| Databáze: | OpenAIRE |
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