Elite controllers: A heterogeneous group of HIV-infected patients
| Autor: | Clara Restrepo, María A Navarrete-Muñoz, José M. Benito, Norma Rallón |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
CD4-Positive T-Lymphocytes medicine.medical_specialty Immunology Human immunodeficiency virus (HIV) HIV Infections Infectious and parasitic diseases RC109-216 Review Article Biology medicine.disease_cause Virus Replication Microbiology elite controllers 03 medical and health sciences Genetic Heterogeneity Internal medicine medicine Hiv infected patients Humans virological control 030304 developmental biology 0303 health sciences Heterogeneous group 030306 microbiology Functional cure Viral Load clinical outcomes Infectious Diseases HIV-1 Parasitology Disease Susceptibility heterogeneity Elite controllers immunological control |
| Zdroj: | Virulence article-version (VoR) Version of Record Virulence, Vol 11, Iss 1, Pp 889-897 (2020) |
| ISSN: | 2150-5608 |
| Popis: | The exceptional group of ECs has been of great help, and will continue to provide invaluable insight with regard to reach a potential functional cure of HIV. However, there is no consensus on the immune correlates associated to this EC phenotype which preclude reaching a potential functional cure of HIV. The existing literature studying this population of individuals has indeed revealed that they are a very heterogeneous group regarding virological, immunological, and even clinical characteristics, and that among ECs only a very small proportion are homogeneous in terms of maintaining virological and immunological control in the long term (the so-called long-term elite controllers, LTECs). Thus, it is of pivotal relevance to identify the LTECs subjects and use them as the right model to redefine immune correlates of a truly functional cure. This review summarizes the evidence of the heterogeneity of HIV elite controllers (ECs) subjects in terms of virological, immunological and clinical outcomes, and the implications of this phenomenon to adequately consider this EC phenotype as the right model of a functional cure. |
| Databáze: | OpenAIRE |
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