Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord
| Autor: | Marc Uram, Terriann Crisp, Hima B. Donepudi, Linda J. Spanos, Veeraiah C. Perni, Janet L. Stafinsky |
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| Rok vydání: | 1991 |
| Předmět: |
Agonist
Male medicine.medical_specialty Serotonin Tetrahydronaphthalenes medicine.drug_class Biguanides Ritanserin Pharmacology Piperazines Internal medicine medicine Reaction Time Animals Serotonin Antagonists Hot plate test Pindolol Injections Spinal Pain Measurement 8-Hydroxy-2-(di-n-propylamino)tetralin Analgesics Chemistry Amphetamines Rats Inbred Strains Rats Endocrinology Spinal Cord Receptors Serotonin Phenylbiguanide medicine.drug Serotonin Agonist |
| Zdroj: | General pharmacology. 22(2) |
| ISSN: | 0306-3623 |
| Popis: | 1. Serotonin (5-HT) and selective 5-HT receptor agonists were administered intrathecally (i.t.) in rats, and the antinociceptive efficacy of these agents was assessed on the tail-flick and hot plate tests. 2. The 5-HT receptor agonists examined in this study included the 5-HT1A agonist 8-hydroxy-N,N-dipropyl-2-aminotetralin (8-OH-DPAT), the 5-HT1B agonist m-trifluoromethylphenylpiperazine (TFMPP), the 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and the 5-HT3 agonist phenylbiguanide (PBG). 3. None of these agents produced significant elevations in tail-flick latency (TFL) at doses which produced elevations in hot plate latency (HPL). 4. In contrast, the i.t. dose of 5-HT which elevated TFL also produced analgesia on the hot plate test. 5. Serotonin-induced elevations in TFL were reversed by pindolol, ritanserin and ICS 205-930, suggesting that 5-HT interacts with more than one 5-HT site in the spinal cord to produce analgesia on the tail-flick test. 6. The finding that ritanserin reversed 5-HT-induced elevations in HPL suggests that the 5-HT2 site is primarily responsible for mediating the spinal antinociceptive effects of 5-HT on the hot plate test. |
| Databáze: | OpenAIRE |
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