The Prostaglandin EP3 Receptor Is an Independent Negative Prognostic Factor for Cervical Cancer Patients

Autor: Aurelia Vattai, Sven Mahner, Christina Kuhn, Yao Ye, Udo Jeschke, Bernd Kost, Caroline Anna Aberl, Sebastian Dietlmeier, Helene Hildegard Heidegger
Rok vydání: 2017
Předmět:
squamous cell carcinoma
0301 basic medicine
Oncology
cervical cancer
Angiogenesis
Uterine Cervical Neoplasms
adenocarcinoma
EP3 receptor
overall survival
prognostic factor
cox regression
lcsh:Chemistry
chemistry.chemical_compound
0302 clinical medicine
Medicine
Receptor
lcsh:QH301-705.5
Spectroscopy
Aged
80 and over
Cervical cancer
General Medicine
Middle Aged
Prognosis
Computer Science Applications
medicine.anatomical_structure
030220 oncology & carcinogenesis
Receptors
Prostaglandin E
EP3 Subtype
Carcinoma
Squamous Cell
Regression Analysis
Adenocarcinoma
Female
lipids (amino acids
peptides
and proteins)
Signal Transduction
Adult
medicine.medical_specialty
Prostaglandin
Article
Catalysis
Inorganic Chemistry
Young Adult
03 medical and health sciences
Internal medicine
Biomarkers
Tumor
Humans
Physical and Theoretical Chemistry
Prostaglandin receptor
Molecular Biology
Cervix
Aged
Neoplasm Staging
business.industry
Proportional hazards model
Organic Chemistry
medicine.disease
Survival Analysis
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
chemistry
business
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 7, p 1571 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 7; Pages: 1571
ISSN: 1422-0067
DOI: 10.3390/ijms18071571
Popis: We know that one of the main risk factors for cervical cancer is an infection with high-risk human papillomavirus (HR-HPV). Prostaglandins and their receptors are very important for the tumour growth and tumour-associated angiogenesis. Little is known about the expression of the Prostaglandin E receptor type 3 (EP3) or the Prostaglandin (PG)E2-EP3 signalling in cervical cancer, so the aim of the study was to analyse the expression of the EP3 receptor in cervical cancer and find prognostic factors in relation to survival; EP3 immunohistological staining of 250 cervical cancer slides was performed and analysed with a semi-quantitative score. The statistical evaluation was performed with Statistical Package for the Social Sciences (SPSS) to evaluate the staining results and the survival analyses of the cervical cancer cases. A significant difference was observed in EP3 expression in Fédération Internationale de Gynécologie et d’Obstétrique (FIGO) stadium I versus FIGO stadium II–IV cases. High expression of EP3 (IRS ≥ 1.5) in cervical cancer patients was correlated with poor prognosis in overall survival rates. Survival in adenocarcinoma (AC) of the cervix was lower than in squamous cell carcinoma (SCC). Cox regression analysis shows that EP3 is an independent prognosticator. In this study we could show that the membrane-bound prostaglandin receptor EP3 is an independent prognosticator for cervical cancer patient survival. Targeting the EP3 receptor seems to be an interesting candidate for endocrine therapy. Therefore, more research is needed on the influence of the receptor system and its influence on cervical cancer growth.
Databáze: OpenAIRE
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