Multivitamin Use and Serum Vitamin B12 Concentrations in Older-Adult Metformin Users in REGARDS, 2003-2007
| Autor: | Winn Cashion, Rebecca S. Williamson, Oluwaseun Odewole, Joshua V. Garn, Vijaya Kancherla, Godfrey P. Oakley, Neil A. Zakai, Suzanne E. Judd |
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| Rok vydání: | 2016 |
| Předmět: |
B Vitamins
Male Time Factors endocrine system diseases lcsh:Medicine Type 2 diabetes Biochemistry Endocrinology Elderly 0302 clinical medicine Medicine and Health Sciences Insulin Medicine 030212 general & internal medicine lcsh:Science education.field_of_study Multidisciplinary Organic Compounds Nutritional Deficiencies food and beverages Anemia Megaloblastic anemia Vitamins Hematology Middle Aged Metformin Type 2 Diabetes 3. Good health Chemistry Vitamin B 12 Vitamin B12 deficiency Micronutrient Deficiencies Physical Sciences Female Multivitamin Research Article medicine.drug Adult medicine.medical_specialty Endocrine Disorders Population 030209 endocrinology & metabolism Cobalamins 03 medical and health sciences Diabetes mellitus Internal medicine Diabetes Mellitus Humans Hypoglycemic Agents Vitamin B12 education Nutrition Aged Diabetic Endocrinology business.industry lcsh:R Organic Chemistry Chemical Compounds Case-control study Biology and Life Sciences nutritional and metabolic diseases Vitamin B 12 Deficiency Odds ratio medicine.disease Hormones Diabetes Mellitus Type 2 Age Groups Metabolic Disorders Case-Control Studies People and Places Dietary Supplements lcsh:Q Population Groupings business Biomarkers |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 8, p e0160802 (2016) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0160802 |
| Popis: | Metformin, an insulin-sensitizing drug, is a first line treatment for type 2 diabetes. Long-term use of metformin has been associated with subsequent reductions in vitamin B12 concentrations. The objective of our study was to determine whether metformin use is associated with lower serum vitamin B12 concentrations in older adults, and whether concurrent use of multivitamins modifies this association. We examined 2,510 participants aged 50 years and over, participating in the national population-based Reasons for Geographic And Racial Differences in Stroke (REGARDS) Study. Multivariable linear and logistic regression models were used to assess associations between multivitamin use and serum vitamin B12 concentrations. We estimated adjusted odds ratios (aOR)s and confidence intervals (CI)s. Results were stratified by three metformin/diabetes sub-groups: 1) participants with diabetes who were metformin users; 2) participants with diabetes who were not metformin users; and 3) participants without diabetes. We found that diabetic metformin users had significantly lower geometric mean serum B12 concentrations (409 pmol/L) than the group with diabetes not taking metformin (485 pmol/L; P |
| Databáze: | OpenAIRE |
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