Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa
| Autor: | Valeria Fazio, Ignazio Senatore, Flora Affuso, Serafino Fazio, Valentina Mercurio, Antonio Ruvolo, Guido Carlomagno, Irina Halinskaya |
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| Přispěvatelé: | Carlomagno, Guido, Mercurio, Valentina, Ruvolo, Antonio, Senatore, Ignazio, Halinskaya, Irina, Fazio, Valeria, Affuso, Flora, Fazio, Serafino |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Multivariate analysis Article Subject business.industry Population Hemodynamics Endocrinology Blood pressure Anorexia nervosa (differential diagnoses) Internal medicine medicine Anorectic Cardiology Endocrine system Clinical significance education business Research Article |
| Zdroj: | ISRN Endocrinology |
| ISSN: | 2090-4649 2090-4630 |
| Popis: | Objective. Anorexia nervosa is a condition of reduced hemodynamic load, characterized by varying degrees of cardiac remodelling, only in part related to reduced body mass; the mechanism for such variability, as well as its clinical significance, remains unknown. Aim of the study was to assess the possible influence of a great number of clinical, biochemical, and endocrine factors on cardiovascular parameters in restrictive anorexia nervosa. Method. Twenty-five female patients hospitalized for restrictive anorexia nervosa underwent extensive cardiovascular, clinical, and biochemical evaluation. Results. Height-adjusted and cardiac workload-matched left ventricular mass was significantly related to several endocrine parameters, blood pressure, and vasoreactivity. On multivariate analysis, IGF/GH ratio and systolic blood pressure were the only independent predictors of height-adjusted ventricular mass (adj- ; ); when matching for cardiac workload, left ventricular mass was independently predicted only by GH and FT3 levels. All effects were independent of patient's weight and BMI. Conclusions. Indices of endocrine impairment seem to be the most relevant determinants of left ventricular hypotrophy in anorectic patients, apparently independent of reduced hemodynamic load and BMI. In particular, IGF/GH ratio and FT3 seem to particularly affect left ventricular mass in this population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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